{"id":"05426cdd-1fa8-5afb-9d8b-4762365137b2","stable_key":"104835a3-b891-5dc4-a6bb-42ab7c6f96c4:butyrate-wound-delay","predicate":"delays","statement":"When mucosal injury exposed proliferating crypt cells to butyrate, epithelial proliferation and wound repair were delayed in the mouse experiments.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"84d439d5-2a35-5326-82ce-9411362fd35a","mechanism_event_label":"Loss of the protective layer changed the response during repair.","subject":{"id":"e7428a7f-d35a-5406-9904-a88984814833","slug":"butyrate","display_name":"Butyrate","entity_type_key":"small_molecule"},"object":{"id":"03ace78c-a033-532b-b330-3b999d758af0","slug":"mouse-crypt-wound-repair","display_name":"Mouse colonic epithelial wound repair","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"84d439d5-2a35-5326-82ce-9411362fd35a","stable_key":"104835a3-b891-5dc4-a6bb-42ab7c6f96c4:butyrate-wound-delay-event","event_type":"observed_relationship","label":"Loss of the protective layer changed the response during repair.","description":"When mucosal injury exposed proliferating crypt cells to butyrate, epithelial proliferation and wound repair were delayed in the mouse experiments.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e7428a7f-d35a-5406-9904-a88984814833","slug":"butyrate","display_name":"Butyrate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"03ace78c-a033-532b-b330-3b999d758af0","slug":"mouse-crypt-wound-repair","display_name":"Mouse colonic epithelial wound repair","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse mucosal injury and local butyrate exposure.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This model does not establish the clinical effect of oral butyrate in every inflammatory bowel condition. Correction record: A published erratum is confirmed by PubMed and publisher/Crossref metadata: Cell 167(4):1137, 2016. The notice body was not available through the accessed publisher endpoints. The main article's Acads/Foxo3 and crypt experiments were read, but the specific effect of the correction remains unassessed. https://pubmed.ncbi.nlm.nih.gov/27814510/","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Butyrate collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"butyrate","display_name":"Butyrate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Loss of the protective layer changed the response during repair.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites. · 2016 · https://pubmed.ncbi.nlm.nih.gov/27264604/ · DOI 10.1016/j.cell.2016.05.018","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"f04c4db4-aaa0-56cf-99d6-cc49943b4d78","evidence_kind":"source_excerpt","locator":"Lines 318-324","start_line":318,"end_line":324,"excerpt":"## butyrate-wound-delay\nLoss of the protective layer changed the response during repair.\nWhen mucosal injury exposed proliferating crypt cells to butyrate, epithelial proliferation and wound repair were delayed in the mouse experiments.\nModel: Mouse mucosal injury and local butyrate exposure.\nLimitations: This model does not establish the clinical effect of oral butyrate in every inflammatory bowel condition. Correction record: A published erratum is confirmed by PubMed and publisher/Crossref metadata: Cell 167(4):1137, 2016. The notice body was not available through the accessed publisher endpoints. The main article's Acads/Foxo3 and crypt experiments were read, but the specific effect of the correction remains unassessed. https://pubmed.ncbi.nlm.nih.gov/27814510/\nEvidence access: Primary abstract\nThe Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites. · 2016 · https://pubmed.ncbi.nlm.nih.gov/27264604/ · DOI 10.1016/j.cell.2016.05.018","model_system":"Mouse mucosal injury and local butyrate exposure.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"33205bb8-dcbe-5d2c-afca-86075d7748d1","stable_key":"import-104835a3-b891-5dc4-a6bb-42ab7c6f96c4","title":"Butyrate: microbial production, fuel use, signaling and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"a1253eb4426fc45d7b7c113028aa4ba2e9f89a9653272f3795437fc222bad558","revision_id":"c2320e65-a252-57a9-8838-7abf3d23400e","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}