{"id":"05119b7b-ca51-5ec0-9f76-1b5cd9f1b098","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:low-dietary-magnesium-increases-ectopy","predicate":"restrains","statement":"Lower Mg intake increased supraventricular ectopy in a randomized crossover feeding study of postmenopausal women.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"9a01b394-7e2e-5bce-9163-dac384df4718","mechanism_event_label":"Controlled magnesium restriction produced its own measurable cardiac electrical effect.","subject":{"id":"1f0c42f0-eaf3-5b86-966d-7ffc8a84872b","slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"},"object":{"id":"a50139de-7ee0-5916-9839-465102c43813","slug":"supraventricular-ectopy","display_name":"Supraventricular ectopy","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"9a01b394-7e2e-5bce-9163-dac384df4718","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:low-dietary-magnesium-increases-ectopy-event","event_type":"observed_intervention","label":"Controlled magnesium restriction produced its own measurable cardiac electrical effect.","description":"Lower Mg intake increased supraventricular ectopy in a randomized crossover feeding study of postmenopausal women.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"bff427ab-35f9-59c2-bb24-fd5953bbaec2","slug":"magnesium-ion","display_name":"Mg2+","entity_type_key":"ion"},"role":"affected-body-pool","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2a870bb5-05a0-5e51-a70c-a9a843a8b571","slug":"copper-ii","display_name":"Copper(II) ion","entity_type_key":"ion"},"role":"independently-varied-dietary-factor","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"1f0c42f0-eaf3-5b86-966d-7ffc8a84872b","slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"a50139de-7ee0-5916-9839-465102c43813","slug":"supraventricular-ectopy","display_name":"Supraventricular ectopy","entity_type_key":"cellular_process"},"role":"object","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence-system","value_text":"22 completers; 81-day low and supplemented Mg periods; Holter monitoring","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"22 completers; 81-day low and supplemented Mg periods; Holter monitoring","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Chemically measured mean intake: 130 mg Mg/day in the low period versus 411 mg/day in the supplemented period; 81 days per period after 10-day equilibration. These are experimental exposures, not recommendations.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Ventricular ectopy alone was not significantly increased; small cohort. Dietary copper varied independently; reported Mg effect was unaffected by copper or sequence.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Magnesium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Controlled magnesium restriction produced its own measurable cardiac electrical effect.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[klevay-2002-ectopy] Low dietary magnesium increases supraventricular ectopy (2002). https://ajcn.nutrition.org/article/S0002-9165%2823%2906154-3/fulltext DOI: 10.1093/ajcn/75.3.550","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Whole-body nutrition; cardiac electrophysiology","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Whole-body nutrition; cardiac electrophysiology","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"4fcd4349-b3c6-51ad-8fed-e813206a1696","evidence_kind":"source_excerpt","locator":"Lines 1318-1330","start_line":1318,"end_line":1330,"excerpt":"### low-dietary-magnesium-increases-ectopy\nLower Mg intake increased supraventricular ectopy in a randomized crossover feeding study of postmenopausal women.\nCondition category: nutrient_deficiency\nnutrient_topic: Magnesium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Controlled magnesium restriction produced its own measurable cardiac electrical effect.\norganism: Human\ntissue_or_cell_type: Whole-body nutrition; cardiac electrophysiology\nexperimental_model: 22 completers; 81-day low and supplemented Mg periods; Holter monitoring\nlimitations: Ventricular ectopy alone was not significantly increased; small cohort. Dietary copper varied independently; reported Mg effect was unaffected by copper or sequence.\nexposure: Chemically measured mean intake: 130 mg Mg/day in the low period versus 411 mg/day in the supplemented period; 81 days per period after 10-day equilibration. These are experimental exposures, not recommendations.\nevidence-system: 22 completers; 81-day low and supplemented Mg periods; Holter monitoring\ntissue: Whole-body nutrition; cardiac electrophysiology\n[klevay-2002-ectopy] Low dietary magnesium increases supraventricular ectopy (2002). https://ajcn.nutrition.org/article/S0002-9165%2823%2906154-3/fulltext DOI: 10.1093/ajcn/75.3.550","model_system":"22 completers; 81-day low and supplemented Mg periods; Holter monitoring","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [klevay-2002-ectopy] Low dietary magnesium increases supraventricular ectopy (2002). https://ajcn.nutrition.org/article/S0002-9165%2823%2906154-3/fulltext DOI: 10.1093/ajcn/75.3.550","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dd101e28-1a2e-5a48-9d1e-809c77514866","stable_key":"import-0f17db03-207f-5910-ac8e-13dfc2f378ce","title":"Magnesium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"e111c412f57143a17e8e65e74e8f7888b5bb9a61099873f4767f527fac19bb07","revision_id":"6b7f04f2-66ed-5859-955f-c2b50d4bf041","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}