{"id":"046f1b77-4d76-5916-85a0-8df8348280ee","stable_key":"548ab9d6-3a9b-5bed-879c-17d03813b636:b2-induced-mouth-skin-lesions","predicate":"induced_unavailability_associated_with_mucocutaneous_lesions","statement":"All six patients developed cheilosis and angular stomatitis during combined restriction/galactoflavin exposure; five developed glossitis and all developed dermatitis.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"47f863e4-271d-592c-a53c-797cde79908a","mechanism_event_label":"Severely reduced usable B2 affected lips, mouth and skin in this historical experiment.","subject":{"id":"86eb1eee-a8d1-539c-8c17-0911f69b6f1b","slug":"riboflavin","display_name":"Riboflavin (vitamin B2)","entity_type_key":"small_molecule"},"object":{"id":"8f16c483-0586-57fe-99b8-0f2338a43d8e","slug":"riboflavin-deficiency-mucocutaneous-lesions","display_name":"Mucocutaneous lesions during riboflavin deficiency","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"47f863e4-271d-592c-a53c-797cde79908a","stable_key":"548ab9d6-3a9b-5bed-879c-17d03813b636:b2-induced-mouth-skin-lesions-event","event_type":"observed_intervention","label":"Severely reduced usable B2 affected lips, mouth and skin in this historical experiment.","description":"All six patients developed cheilosis and angular stomatitis during combined restriction/galactoflavin exposure; five developed glossitis and all developed dermatitis.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"da6825a9-c81a-5f18-bb3d-11401d04eec8","slug":"galactoflavin","display_name":"Galactoflavin","entity_type_key":"small_molecule"},"role":"antagonist","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"86eb1eee-a8d1-539c-8c17-0911f69b6f1b","slug":"riboflavin","display_name":"Riboflavin (vitamin B2)","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8f16c483-0586-57fe-99b8-0f2338a43d8e","slug":"riboflavin-deficiency-mucocutaneous-lesions","display_name":"Mucocutaneous lesions during riboflavin deficiency","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"experimental_model","value_text":"Historical induced-depletion study in six men with inoperable cancers; no healthy randomized control group.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Low-riboflavin semisynthetic diet plus galactoflavin antagonist, followed by riboflavin replacement; three also received oral antibiotics.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Advanced cancer, antagonist exposure and antibiotic use in three patients; lesions are not diagnostic of B2 deficiency by appearance alone.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Riboflavin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"riboflavin","display_name":"Riboflavin (vitamin B2)","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Severely reduced usable B2 affected lips, mouth and skin in this historical experiment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b2-lane1964] THE RAPID INDUCTION OF HUMAN RIBOFLAVIN DEFICIENCY WITH GALACTOFLAVIN (1964). https://pubmed.ncbi.nlm.nih.gov/14135487/ DOI: 10.1172/jci104921","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Oral mucosa, lips and skin","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"dda0a539-43fb-54fd-af22-66a55300f25b","evidence_kind":"source_excerpt","locator":"Lines 1789-1799","start_line":1789,"end_line":1799,"excerpt":"### b2-induced-mouth-skin-lesions\nAll six patients developed cheilosis and angular stomatitis during combined restriction/galactoflavin exposure; five developed glossitis and all developed dermatitis.\nCondition category: nutrient_deficiency\nnutrient_topic: Riboflavin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Severely reduced usable B2 affected lips, mouth and skin in this historical experiment.\norganism: Homo sapiens\ntissue_or_cell_type: Oral mucosa, lips and skin\nexperimental_model: Historical induced-depletion study in six men with inoperable cancers; no healthy randomized control group.\nlimitations: Advanced cancer, antagonist exposure and antibiotic use in three patients; lesions are not diagnostic of B2 deficiency by appearance alone.\nexposure: Low-riboflavin semisynthetic diet plus galactoflavin antagonist, followed by riboflavin replacement; three also received oral antibiotics.\n[b2-lane1964] THE RAPID INDUCTION OF HUMAN RIBOFLAVIN DEFICIENCY WITH GALACTOFLAVIN (1964). https://pubmed.ncbi.nlm.nih.gov/14135487/ DOI: 10.1172/jci104921","model_system":"Historical induced-depletion study in six men with inoperable cancers; no healthy randomized control group.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b2-lane1964] THE RAPID INDUCTION OF HUMAN RIBOFLAVIN DEFICIENCY WITH GALACTOFLAVIN (1964). https://pubmed.ncbi.nlm.nih.gov/14135487/ DOI: 10.1172/jci104921","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4f7c9578-82bf-5e2d-b5c4-72a79fb4f6af","stable_key":"import-548ab9d6-3a9b-5bed-879c-17d03813b636","title":"Riboflavin: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"680cb6bc8249877f2410f551807f10d390fdd719014137d7414ba3420e29228d","revision_id":"7a61e299-908d-5372-860b-99ed190f9d7a","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}