{"id":"04569cc1-b77f-5a4b-aef8-f4a98e2eac17","stable_key":"b3c3f45a-50fb-5b79-98d7-5e5228df00db:cold-cold-metabolic-rate","predicate":"increases","statement":"Immersion at 14 degrees C lowered rectal temperature and increased metabolic rate by 350%, with heart rate and systolic and diastolic blood pressure rising by 5, 7 and 8%.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"881dc2c6-f049-5e16-9283-63914b02cba1","mechanism_event_label":"At 14 degrees the body burns roughly four and a half times as much energy as at rest.","subject":{"id":"96a7dff2-caf4-51c1-93c4-c9ed08c05c9a","slug":"cold-water-immersion","display_name":"Cold water immersion","entity_type_key":"drug"},"object":{"id":"f852c25a-227b-571c-9f86-257dd9c90113","slug":"metabolic-rate","display_name":"Whole-body metabolic rate","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"881dc2c6-f049-5e16-9283-63914b02cba1","stable_key":"b3c3f45a-50fb-5b79-98d7-5e5228df00db:cold-cold-metabolic-rate-event","event_type":"observed_intervention","label":"At 14 degrees the body burns roughly four and a half times as much energy as at rest.","description":"Immersion at 14 degrees C lowered rectal temperature and increased metabolic rate by 350%, with heart rate and systolic and diastolic blood pressure rising by 5, 7 and 8%.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8d7989a0-37d9-5c72-84bb-29d7d4a5a932","slug":"core-temperature","display_name":"Core (rectal) body temperature","entity_type_key":"cellular_process"},"role":"lowered_property","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"96a7dff2-caf4-51c1-93c4-c9ed08c05c9a","slug":"cold-water-immersion","display_name":"Cold water immersion","entity_type_key":"drug"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"f852c25a-227b-571c-9f86-257dd9c90113","slug":"metabolic-rate","display_name":"Whole-body metabolic rate","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/cold-research/10751106.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"d018fda7c67dc61bb0d4a38ddfd7850e7252897587c5a4477607271b10d42291\", \"start_char\": 0, \"end_char\": 2332, \"text_sha256\": \"d018fda7c67dc61bb0d4a38ddfd7850e7252897587c5a4477607271b10d42291\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Young men during 1-hour head-out immersions at 32, 20 and 14 degrees C","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"One hour head-out immersion at three water temperatures","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The thermoneutral arm separates hydrostatic pressure from cold. Cortisol did not rise at any temperature, which bears directly on calling immersion a stress response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake.","comparator":null,"unit":null,"notes":"","entity":{"slug":"cold-water-immersion","display_name":"Cold water immersion","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"At 14 degrees the body burns roughly four and a half times as much energy as at rest.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[cold-p10751106] Human physiological responses to immersion into water of different temperatures. (2000). https://pubmed.ncbi.nlm.nih.gov/10751106/ DOI: 10.1007/s004210050065","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Whole body","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"5735e09d-b962-5270-9a39-8dca7e188b1f","evidence_kind":"source_excerpt","locator":"Lines 182-193","start_line":182,"end_line":193,"excerpt":"### cold-cold-metabolic-rate\nImmersion at 14 degrees C lowered rectal temperature and increased metabolic rate by 350%, with heart rate and systolic and diastolic blood pressure rising by 5, 7 and 8%.\nCondition category: normal\nnutrient_topic: Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake.\nplain_language: At 14 degrees the body burns roughly four and a half times as much energy as at rest.\norganism: Human\ntissue_or_cell_type: Whole body\nexperimental_model: Young men during 1-hour head-out immersions at 32, 20 and 14 degrees C\nlimitations: The thermoneutral arm separates hydrostatic pressure from cold. Cortisol did not rise at any temperature, which bears directly on calling immersion a stress response.\nexposure: One hour head-out immersion at three water temperatures\nevidence_span: {\"source_cache\": \"artifacts/cold-research/10751106.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"d018fda7c67dc61bb0d4a38ddfd7850e7252897587c5a4477607271b10d42291\", \"start_char\": 0, \"end_char\": 2332, \"text_sha256\": \"d018fda7c67dc61bb0d4a38ddfd7850e7252897587c5a4477607271b10d42291\"}\n[cold-p10751106] Human physiological responses to immersion into water of different temperatures. (2000). https://pubmed.ncbi.nlm.nih.gov/10751106/ DOI: 10.1007/s004210050065","model_system":"Young men during 1-hour head-out immersions at 32, 20 and 14 degrees C","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [cold-p10751106] Human physiological responses to immersion into water of different temperatures. (2000). https://pubmed.ncbi.nlm.nih.gov/10751106/ DOI: 10.1007/s004210050065","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"feeccadc-1392-573e-a0b5-0939ee5de6e2","stable_key":"import-b3c3f45a-50fb-5b79-98d7-5e5228df00db","title":"Cold water immersion: cold sensing, heat production, the catecholamine axis and what repeated exposure changes (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"557f074d372c49c502c34e648651aff7ebf2c8816305d2d2f08e338a7e96a5f0","revision_id":"ecc19e8d-40db-5b5d-b98e-0507f645976c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}