{"id":"044d8168-b315-5cff-844e-e13304657793","stable_key":"e3f6ce02-0bd7-5103-acc1-68503ab6751b:nmda-receptor-number","predicate":"increases_in_recorded_comparison","statement":"Chronic ALCAR attenuated loss of measured NMDA receptor sites in aged rat brain.","claim_class":"observational","status":"source_recorded","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"d772222b-ca6b-5442-a082-ecd2ad56b539","mechanism_event_label":"Chronic ALCAR attenuated loss of measured NMDA receptor sites in aged rat brain.","subject":{"id":"5ce394a9-6ec6-56dd-866f-37d85c0556e4","slug":"acetylcarnitine","display_name":"Acetyl-L-carnitine","entity_type_key":"small_molecule"},"object":{"id":"8936c0b8-0eca-567a-9b20-5f0e4de3931f","slug":"rat-aged-nmda-binding-sites","display_name":"Aged-rat NMDA receptor binding-site abundance","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d772222b-ca6b-5442-a082-ecd2ad56b539","stable_key":"e3f6ce02-0bd7-5103-acc1-68503ab6751b:nmda-receptor-number-event","event_type":"experimental_observation","label":"Chronic ALCAR attenuated loss of measured NMDA receptor sites in aged rat brain.","description":"### nmda-receptor-number\n\nChronic ALCAR attenuated loss of measured NMDA receptor sites in aged rat brain.\nThe finding is receptor-site abundance, not proof of direct receptor activation or a human cognitive benefit. Dose and subtype were not resolved from the indexed abstract.\nModel and exposure: Twenty-four-month-old rats; ALCAR in drinking water for six months; hippocampus, frontal cortex, striatum.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: Age-dependent loss of NMDA receptors in hippocampus, striatum, and frontal cortex of the rat: prevention by acetyl-L-carnitine. | 1994 | https://pubmed.ncbi.nlm.nih.gov/7969747/ | https://doi.org/10.1007/bf00967446 | Access: Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5ce394a9-6ec6-56dd-866f-37d85c0556e4","slug":"acetylcarnitine","display_name":"Acetyl-L-carnitine","entity_type_key":"small_molecule"},"role":"tested factor","stoichiometry":null,"state_label":"Six-month ALCAR treatment","sequence_order":0,"notes":""},{"entity":{"id":"8936c0b8-0eca-567a-9b20-5f0e4de3931f","slug":"rat-aged-nmda-binding-sites","display_name":"Aged-rat NMDA receptor binding-site abundance","entity_type_key":"cellular_process"},"role":"measured outcome","stoichiometry":null,"state_label":"increase","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_contrast","value_text":"{\"intervention\": \"Six-month ALCAR treatment\", \"comparator\": \"Aged comparison animals\", \"endpoint\": \"Chronic ALCAR attenuated loss of measured NMDA receptor sites in aged rat brain.\", \"effect_direction\": \"increase\", \"combination\": \"single\", \"conditions\": []}","comparator":null,"unit":null,"notes":"Explicit extracted experimental comparison; source-derived draft.","entity":null},{"dimension":"experimental_model","value_text":"Twenty-four-month-old rats; ALCAR in drinking water for six months; hippocampus, frontal cortex, striatum.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Source-derived curation with stated access limits; ungraded, not independent replication.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Acetyl-L-carnitine collection; exact intervention and molecular form govern interpretation.","comparator":null,"unit":null,"notes":"","entity":{"slug":"acetylcarnitine","display_name":"Acetyl-L-carnitine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Chronic ALCAR attenuated loss of measured NMDA receptor sites in aged rat brain.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Age-dependent loss of NMDA receptors in hippocampus, striatum, and frontal cortex of the rat: prevention by acetyl-L-carnitine. | https://pubmed.ncbi.nlm.nih.gov/7969747/ | https://doi.org/10.1007/bf00967446","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference nmda-receptor-number; The finding is receptor-site abundance, not proof of direct receptor activation or a human cognitive benefit. Dose and subtype were not resolved from the indexed abstract.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"f84dc300-39b5-507f-9a78-ef3f9b8175a7","evidence_kind":"source_excerpt","locator":"Lines 180-186","start_line":180,"end_line":186,"excerpt":"### nmda-receptor-number\n\nChronic ALCAR attenuated loss of measured NMDA receptor sites in aged rat brain.\nThe finding is receptor-site abundance, not proof of direct receptor activation or a human cognitive benefit. Dose and subtype were not resolved from the indexed abstract.\nModel and exposure: Twenty-four-month-old rats; ALCAR in drinking water for six months; hippocampus, frontal cortex, striatum.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: Age-dependent loss of NMDA receptors in hippocampus, striatum, and frontal cortex of the rat: prevention by acetyl-L-carnitine. | 1994 | https://pubmed.ncbi.nlm.nih.gov/7969747/ | https://doi.org/10.1007/bf00967446 | Access: Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.","model_system":"Twenty-four-month-old rats; ALCAR in drinking water for six months; hippocampus, frontal cortex, striatum.","directness":"reported_statement","verification_status":"source_recorded","notes":"Original paraphrase in the retained reviewed reference, not a verbatim primary-paper quotation. Access level is explicit.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2588f904-245a-597a-8a12-65118013fb90","stable_key":"import-e3f6ce02-0bd7-5103-acc1-68503ab6751b","title":"Acetyl-L-carnitine: detailed mechanisms of action (reviewed 6 October 2026)","document_type":"imported_text","citation_label":"AI-assisted original review of primary studies and clearly identified official records. Exact primary access is stated; no independent replication is claimed.","file_path":"","sha256":"84cc82d6fbb0fd5d73c4ce779e9f88e7f0184ba2d29b18ad0f153815380f2975","revision_id":"dac7a950-dbe5-5c7a-9c70-2ea711d5c71a","review_status":"source_recorded","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}