{"id":"0443c88c-80a4-5553-b05e-5f93a22879fe","stable_key":"ae1ed35d-8ce7-5936-9067-a641374bbf79:carnosine-zinc-indomethacin","predicate":"attenuates","statement":"Zinc-carnosine coadministration prevented the significant permeability rise seen during the placebo/indomethacin arm.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"24c5e89b-737e-55e9-a876-2aadbbd7e2d2","mechanism_event_label":"The complex changed a human intestinal-barrier marker.","subject":{"id":"a1ed4282-d9fa-5acb-94f3-d4cf19dfd693","slug":"zinc-carnosine","display_name":"Zinc L-carnosine complex / polaprezinc","entity_type_key":"chemical_species"},"object":{"id":"c7e461b1-ec91-5563-b191-6e1b8f9415cd","slug":"human-indomethacin-permeability","display_name":"Human indomethacin-associated intestinal permeability","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"24c5e89b-737e-55e9-a876-2aadbbd7e2d2","stable_key":"ae1ed35d-8ce7-5936-9067-a641374bbf79:carnosine-zinc-indomethacin-event","event_type":"observed_relationship","label":"The complex changed a human intestinal-barrier marker.","description":"Zinc-carnosine coadministration prevented the significant permeability rise seen during the placebo/indomethacin arm.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"a1ed4282-d9fa-5acb-94f3-d4cf19dfd693","slug":"zinc-carnosine","display_name":"Zinc L-carnosine complex / polaprezinc","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"c7e461b1-ec91-5563-b191-6e1b8f9415cd","slug":"human-indomethacin-permeability","display_name":"Human indomethacin-associated intestinal permeability","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"49c806c2-7041-5020-8b3b-fa04ffa122ac","slug":"zinc-ion","display_name":"Zinc(II) ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"9998eb9b-0d09-58c9-885b-a442477dec8d","slug":"carnosine","display_name":"L-Carnosine / beta-alanyl-L-histidine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Ten healthy volunteers; 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five-day crossover; lactulose:rhamnose measurement.\nLimitations: Small trial and surrogate endpoint; not free-carnosine efficacy.\nEvidence access: Primary abstract\nZinc carnosine, a health food supplement that stabilises small bowel integrity and stimulates gut repair processes. · 2007 · https://pubmed.ncbi.nlm.nih.gov/16777920/ · DOI 10.1136/gut.2006.099929","model_system":"Ten healthy volunteers; five-day crossover; lactulose:rhamnose measurement.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"87dc5af2-4eb6-5980-b7e0-bf3697b1156e","stable_key":"import-ae1ed35d-8ce7-5936-9067-a641374bbf79","title":"Carnosine: synthesis, transport, carbonyl chemistry and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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