{"id":"04409d30-5519-5dfe-8aeb-72bfe055dfa1","stable_key":"46d15d9e-d3b5-544d-ba01-b785aa3e4f42:b1-benfotiamine-kidney-null","predicate":"does_not_significantly_reduce","statement":"Twelve weeks of benfotiamine did not significantly reduce urinary albumin or KIM-1 excretion despite improved thiamine status.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"21cd5dfd-5796-5716-a084-a92582e0f887","mechanism_event_label":"Higher vitamin status did not translate into the expected kidney-marker improvement.","subject":{"id":"bbd53f1e-98b5-50b8-8de8-b414b34b35a2","slug":"benfotiamine","display_name":"Benfotiamine","entity_type_key":"small_molecule"},"object":{"id":"c12568d8-842f-5325-b458-c562a0ed8126","slug":"urinary-albumin-excretion","display_name":"Urinary albumin excretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"21cd5dfd-5796-5716-a084-a92582e0f887","stable_key":"46d15d9e-d3b5-544d-ba01-b785aa3e4f42:b1-benfotiamine-kidney-null-event","event_type":"observed_intervention","label":"Higher vitamin status did not translate into the expected kidney-marker improvement.","description":"Twelve weeks of benfotiamine did not significantly reduce urinary albumin or KIM-1 excretion despite improved thiamine status.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"7433a2e4-5b82-5bac-a00f-90010a30e0f8","slug":"urinary-kim1-excretion","display_name":"Urinary kidney injury molecule 1 excretion","entity_type_key":"cellular_process"},"role":"parallel_endpoint","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"50b43772-b960-5f2d-ab07-8f7b4ed5366d","slug":"havcr1","display_name":"Kidney injury molecule 1 / HAVCR1","entity_type_key":"protein"},"role":"measured_protein_identity","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"36b7c3eb-068b-500f-af1c-078829df1ecc","slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"},"role":"metabolic_relation","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"bbd53f1e-98b5-50b8-8de8-b414b34b35a2","slug":"benfotiamine","display_name":"Benfotiamine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"c12568d8-842f-5325-b458-c562a0ed8126","slug":"urinary-albumin-excretion","display_name":"Urinary albumin excretion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"82 participants already receiving ACE inhibitor or ARB therapy.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Benfotiamine 900 mg/day versus placebo for 12 weeks on ACE inhibitor/ARB therapy; study exposure only.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Different compound, population and treatment context from the native-thiamine pilot; not a direct replication or proven explanation for the difference.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Thiamine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Higher vitamin status did not translate into the expected kidney-marker improvement.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b1-alkhalaf2010] A double-blind, randomized, placebo-controlled clinical trial on benfotiamine treatment in patients with diabetic nephropathy (2010). https://pubmed.ncbi.nlm.nih.gov/20413516/ DOI: 10.2337/dc09-2241","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Urine","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"1dbff350-3dcc-565e-b6a2-03fdad3b1682","evidence_kind":"source_excerpt","locator":"Lines 1855-1865","start_line":1855,"end_line":1865,"excerpt":"### b1-benfotiamine-kidney-null\nTwelve weeks of benfotiamine did not significantly reduce urinary albumin or KIM-1 excretion despite improved thiamine status.\nCondition category: normal\nnutrient_topic: Thiamine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Higher vitamin status did not translate into the expected kidney-marker improvement.\norganism: Homo sapiens\ntissue_or_cell_type: Urine\nexperimental_model: 82 participants already receiving ACE inhibitor or ARB therapy.\nlimitations: Different compound, population and treatment context from the native-thiamine pilot; not a direct replication or proven explanation for the difference.\nexposure: Benfotiamine 900 mg/day versus placebo for 12 weeks on ACE inhibitor/ARB therapy; study exposure only.\n[b1-alkhalaf2010] A double-blind, randomized, placebo-controlled clinical trial on benfotiamine treatment in patients with diabetic nephropathy (2010). https://pubmed.ncbi.nlm.nih.gov/20413516/ DOI: 10.2337/dc09-2241","model_system":"82 participants already receiving ACE inhibitor or ARB therapy.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b1-alkhalaf2010] A double-blind, randomized, placebo-controlled clinical trial on benfotiamine treatment in patients with diabetic nephropathy (2010). https://pubmed.ncbi.nlm.nih.gov/20413516/ DOI: 10.2337/dc09-2241","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"158d2c03-ac8c-589f-8270-c468165ae346","stable_key":"import-46d15d9e-d3b5-544d-ba01-b785aa3e4f42","title":"Thiamine: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"f376512fb3310141315548015b387833e3af45146e73fb73cd02cee20e4ddb9c","revision_id":"53bc5eda-dec8-58cc-a56f-a9eb4ab036ef","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}