{"id":"041fb51a-13c8-5f86-9c64-f17d27b4e95e","stable_key":"d8050016-13c9-5391-9d61-63de73590053:zeaxanthin-primate-depletion","predicate":"depletes","statement":"The 2004 cohort had no detectable macular pigment before repletion.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"422b4569-0ff8-5b04-b631-e60996fae122","mechanism_event_label":"The depleted animals lacked the measurable pigment pool.","subject":{"id":"acf931e4-ebb8-5915-be60-4c02da2158a3","slug":"rhesus-xanthophyll-deprivation","display_name":"Lifelong xanthophyll-free diet in rhesus monkeys","entity_type_key":"chemical_species"},"object":{"id":"21754159-d019-5bb5-9377-f8b91a596e2f","slug":"rhesus-macular-pigment","display_name":"Rhesus macular pigment content","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"422b4569-0ff8-5b04-b631-e60996fae122","stable_key":"d8050016-13c9-5391-9d61-63de73590053:zeaxanthin-primate-depletion-event","event_type":"biochemical_relationship","label":"The depleted animals lacked the measurable pigment pool.","description":"The 2004 cohort had no detectable macular pigment before repletion.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"acf931e4-ebb8-5915-be60-4c02da2158a3","slug":"rhesus-xanthophyll-deprivation","display_name":"Lifelong xanthophyll-free diet in rhesus monkeys","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"21754159-d019-5bb5-9377-f8b91a596e2f","slug":"rhesus-macular-pigment","display_name":"Rhesus macular pigment content","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/zeaxanthin-research/15326146.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"2feb9366dc3d6fc9886076332f2e4ebc33603b94b113bc130163226845f7cea2\", \"start_char\": 0, \"end_char\": 1572, \"text_sha256\": \"2feb9366dc3d6fc9886076332f2e4ebc33603b94b113bc130163226845f7cea2\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Long-term dietary depletion followed by single-pigment repletion","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Lifelong xanthophyll-free diet; six animals received pure zeaxanthin 2.2 mg/kg/day for 24–56 weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Extreme combined-xanthophyll depletion is not isolated human zeaxanthin deficiency or a clinical diagnostic threshold.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Zeaxanthin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"zeaxanthin","display_name":"Dietary (3R,3-prime-R)-zeaxanthin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Rhesus macaques","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The depleted animals lacked the measurable pigment pool.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[zeaxanthin-p15326146] Nutritional manipulation of primate retinas, I: effects of lutein or zeaxanthin supplements on serum and macular pigment in xanthophyll-free rhesus monkeys. (2004). https://pubmed.ncbi.nlm.nih.gov/15326146/ DOI: 10.1167/iovs.02-1243","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Serum and macular pigment","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"08e7bd49-3838-5412-92e0-071e28e2e071","evidence_kind":"source_excerpt","locator":"Lines 886-897","start_line":886,"end_line":897,"excerpt":"### zeaxanthin-primate-depletion\nThe 2004 cohort had no detectable macular pigment before repletion.\nCondition category: nutrient_deficiency\nnutrient_topic: Zeaxanthin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The depleted animals lacked the measurable pigment pool.\norganism: Rhesus macaques\ntissue_or_cell_type: Serum and macular pigment\nexperimental_model: Long-term dietary depletion followed by single-pigment repletion\nlimitations: Extreme combined-xanthophyll depletion is not isolated human zeaxanthin deficiency or a clinical diagnostic threshold.\nexposure: Lifelong xanthophyll-free diet; six animals received pure zeaxanthin 2.2 mg/kg/day for 24–56 weeks\nevidence_span: {\"source_cache\": \"artifacts/zeaxanthin-research/15326146.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"2feb9366dc3d6fc9886076332f2e4ebc33603b94b113bc130163226845f7cea2\", \"start_char\": 0, \"end_char\": 1572, \"text_sha256\": \"2feb9366dc3d6fc9886076332f2e4ebc33603b94b113bc130163226845f7cea2\"}\n[zeaxanthin-p15326146] Nutritional manipulation of primate retinas, I: effects of lutein or zeaxanthin supplements on serum and macular pigment in xanthophyll-free rhesus monkeys. 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