{"id":"041fa033-cfad-55ff-9f8a-6f9216e2d66b","stable_key":"79018983-9179-5c1a-8e7a-d6f47a13582b:ki-lamb-il8","predicate":"reduces","statement":"Pulmonary IL-8 and RSV antigen expression were lower in KI-treated newborn lambs.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"d38dcd61-0460-580b-b4c8-f6a4fe1e4c5a","mechanism_event_label":"Inflammatory and viral markers fell in the animal study.","subject":{"id":"d6a7fe6a-d90e-5fad-acf4-4971b24fa8d7","slug":"potassium-iodide","display_name":"Potassium iodide","entity_type_key":"chemical_species"},"object":{"id":"f6e84f88-dd57-5533-a745-7ef0384c43f5","slug":"lamb-pulmonary-il8-expression","display_name":"Pulmonary IL-8 expression in lambs","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d38dcd61-0460-580b-b4c8-f6a4fe1e4c5a","stable_key":"79018983-9179-5c1a-8e7a-d6f47a13582b:ki-lamb-il8-event","event_type":"observed_relationship","label":"Inflammatory and viral markers fell in the animal study.","description":"Pulmonary IL-8 and RSV antigen expression were lower in KI-treated newborn lambs.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d6a7fe6a-d90e-5fad-acf4-4971b24fa8d7","slug":"potassium-iodide","display_name":"Potassium iodide","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f6e84f88-dd57-5533-a745-7ef0384c43f5","slug":"lamb-pulmonary-il8-expression","display_name":"Pulmonary IL-8 expression in lambs","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Newborn and three-week-old lamb RSV experiments; oral KI given by intragastric gavage.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure_category","value_text":"Study-specific exposure, including pharmacological and in-vitro conditions; normal is the schema fallback outside the three availability categories.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Animal disease model; no human antiviral efficacy established. LPO inhibition supports pathway involvement, not an exclusively LPO mechanism.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Potassium iodide research collection; shared-anion and comparator studies are not all KI interventions.","comparator":null,"unit":null,"notes":"","entity":{"slug":"potassium-iodide","display_name":"Potassium iodide","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"Inflammatory and viral markers fell in the animal study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Increased concentration of iodide in airway secretions is associated with reduced respiratory syncytial virus disease severity. · 2014 · https://pubmed.ncbi.nlm.nih.gov/24053146/ · DOI 10.1165/rcmb.2012-0529oc","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"dd905526-5531-5342-ae08-dd9bb4fe876b","evidence_kind":"source_excerpt","locator":"Lines 112-118","start_line":112,"end_line":118,"excerpt":"## ki-lamb-il8\nInflammatory and viral markers fell in the animal study.\nPulmonary IL-8 and RSV antigen expression were lower in KI-treated newborn lambs.\nModel: Newborn and three-week-old lamb RSV experiments; oral KI given by intragastric gavage.\nLimitations: Animal disease model; no human antiviral efficacy established. LPO inhibition supports pathway involvement, not an exclusively LPO mechanism.\nEvidence location: Primary abstract\nIncreased concentration of iodide in airway secretions is associated with reduced respiratory syncytial virus disease severity. · 2014 · https://pubmed.ncbi.nlm.nih.gov/24053146/ · DOI 10.1165/rcmb.2012-0529oc","model_system":"Newborn and three-week-old lamb RSV experiments; oral KI given by intragastric gavage.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Curation paraphrase; primary evidence location and source kind retained above.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc3ce411-f68f-5eb8-87c1-1592665f9cb6","stable_key":"import-79018983-9179-5c1a-8e7a-d6f47a13582b","title":"Potassium iodide: thyroid and non-thyroid mechanisms, interactions and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-study references, chemical references and label statements individually identified. 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