{"id":"03c51be9-372e-5867-857e-fc2b6aa71132","stable_key":"74ef5bba-ee14-531c-b1bf-d1f297c56bb6:fisetin-mouse-geraldol","predicate":"converted_to","statement":"After 223 mg/kg intraperitoneal fisetin in mice, chromatography and mass spectrometry identified geraldol as a methoxylated metabolite.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"7b38aa89-3117-58ec-b16d-efe0c1b57798","mechanism_event_label":"The parent compound becomes a distinct molecule.","subject":{"id":"dee05061-c3f3-5226-8054-dd58b76a585d","slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"},"object":{"id":"9fdb2610-ab87-5de2-9658-ed83bc42b3fc","slug":"geraldol","display_name":"Geraldol / 3-prime-O-methylfisetin","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"7b38aa89-3117-58ec-b16d-efe0c1b57798","stable_key":"74ef5bba-ee14-531c-b1bf-d1f297c56bb6:fisetin-mouse-geraldol-event","event_type":"observed_relationship","label":"The parent compound becomes a distinct molecule.","description":"After 223 mg/kg intraperitoneal fisetin in mice, chromatography and mass spectrometry identified geraldol as a methoxylated metabolite.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"dee05061-c3f3-5226-8054-dd58b76a585d","slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9fdb2610-ab87-5de2-9658-ed83bc42b3fc","slug":"geraldol","display_name":"Geraldol / 3-prime-O-methylfisetin","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse disposition experiment; authentic standard comparison.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"High injected animal exposure; not human oral pharmacokinetics.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Fisetin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The parent compound becomes a distinct molecule.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Fisetin disposition and metabolism in mice: Identification of geraldol as an active metabolite. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21840301/ · DOI 10.1016/j.bcp.2011.07.097","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"57998300-6fd9-510e-8944-4cea5fa22b8c","evidence_kind":"source_excerpt","locator":"Lines 24-30","start_line":24,"end_line":30,"excerpt":"## fisetin-mouse-geraldol\nThe parent compound becomes a distinct molecule.\nAfter 223 mg/kg intraperitoneal fisetin in mice, chromatography and mass spectrometry identified geraldol as a methoxylated metabolite.\nModel: Mouse disposition experiment; authentic standard comparison.\nLimitations: High injected animal exposure; not human oral pharmacokinetics.\nEvidence access: Primary abstract\nFisetin disposition and metabolism in mice: Identification of geraldol as an active metabolite. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21840301/ · DOI 10.1016/j.bcp.2011.07.097","model_system":"Mouse disposition experiment; authentic standard comparison.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1108bfff-6504-5152-a51f-ff3d7c27c282","stable_key":"import-74ef5bba-ee14-531c-b1bf-d1f297c56bb6","title":"Fisetin: metabolism, cell-state responses and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"c30e0764cd34bd062cfcbfaf32357ef29dfda30e7d4153c545178140f5054e09","revision_id":"40ff52c0-f4b9-5820-8abb-ff002c6364a4","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}