{"id":"035906d7-e105-55c0-9cfe-df0514cdd3df","stable_key":"53d9b98d-e3a0-5416-bc88-adbe42a8cb1b:curcumin-nrf2-stability","predicate":"increases","statement":"Curcumin stabilized Nrf2 protein in the murine epidermal-cell experiments.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"1eb7075d-5d6e-5752-806a-b19bba616a70","mechanism_event_label":"The cell retained more of a stress-response regulator.","subject":{"id":"0e625439-d093-5d1b-8713-dcfdafcf6811","slug":"curcumin","display_name":"Curcumin","entity_type_key":"small_molecule"},"object":{"id":"a7c7deb4-b8f2-5af2-b7d2-615cfffddc03","slug":"mouse-nrf2-protein-stability","display_name":"Mouse Nrf2 protein stability","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"1eb7075d-5d6e-5752-806a-b19bba616a70","stable_key":"53d9b98d-e3a0-5416-bc88-adbe42a8cb1b:curcumin-nrf2-stability-event","event_type":"biochemical_relationship","label":"The cell retained more of a stress-response regulator.","description":"Curcumin stabilized Nrf2 protein in the murine epidermal-cell experiments.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0e625439-d093-5d1b-8713-dcfdafcf6811","slug":"curcumin","display_name":"Curcumin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"a7c7deb4-b8f2-5af2-b7d2-615cfffddc03","slug":"mouse-nrf2-protein-stability","display_name":"Mouse Nrf2 protein stability","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/curcumin-research/31972171.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"0a05e877dfe677824dea390c30634719eba641ed122c2480147ce2e73bf05936\", \"start_char\": 0, \"end_char\": 1591, \"text_sha256\": \"0a05e877dfe677824dea390c30634719eba641ed122c2480147ce2e73bf05936\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse epidermal-cell and skin experiments, siRNA and receptor-construct assays","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Curcumin versus tetrahydrocurcumin; Nrf2 siRNA and Keap1 C151S construct","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Cell exposures and construct-origin details are not available in the indexed abstract. Results do not establish human systemic target engagement.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Curcumin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"curcumin","display_name":"Curcumin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Mus musculus; transfected construct species not resolved in indexed abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The cell retained more of a stress-response regulator.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[curcumin-p31972171] Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification. 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Results do not establish human systemic target engagement.\nexposure: Curcumin versus tetrahydrocurcumin; Nrf2 siRNA and Keap1 C151S construct\nevidence_span: {\"source_cache\": \"artifacts/curcumin-research/31972171.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"0a05e877dfe677824dea390c30634719eba641ed122c2480147ce2e73bf05936\", \"start_char\": 0, \"end_char\": 1591, \"text_sha256\": \"0a05e877dfe677824dea390c30634719eba641ed122c2480147ce2e73bf05936\"}\n[curcumin-p31972171] Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification. (2020). https://pubmed.ncbi.nlm.nih.gov/31972171/ DOI: 10.1016/j.bcp.2020.113820","model_system":"Mouse epidermal-cell and skin experiments, siRNA and receptor-construct assays","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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