{"id":"0335ca83-f012-5be8-9767-fa556795b7a6","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-vascular-dilation","predicate":"improves","statement":"The taurine arm in the same prehypertension trial improved both endothelium-dependent and endothelium-independent vasodilation.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"b4042285-af56-573b-8bae-c627e04af86b","mechanism_event_label":"Blood-vessel function changed along with blood pressure.","subject":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"object":{"id":"4567e0ef-ffa0-5e64-bdf6-59fd6e632e10","slug":"human-taurine-vascular-dilation","display_name":"Vasodilation in the 120-participant taurine trial","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b4042285-af56-573b-8bae-c627e04af86b","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-vascular-dilation-event","event_type":"observed_relationship","label":"Blood-vessel function changed along with blood pressure.","description":"The taurine arm in the same prehypertension trial improved both endothelium-dependent and endothelium-independent vasodilation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"4567e0ef-ffa0-5e64-bdf6-59fd6e632e10","slug":"human-taurine-vascular-dilation","display_name":"Vasodilation in the 120-participant taurine trial","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Same 120-person randomized study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Clinical and vascular endpoints from one trial are not independent trials.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Taurine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Blood-vessel function changed along with blood pressure.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Taurine Supplementation Lowers Blood Pressure and Improves Vascular Function in Prehypertension: Randomized, Double-Blind, Placebo-Controlled Study. · 2016 · https://pubmed.ncbi.nlm.nih.gov/26781281/ · DOI 10.1161/HYPERTENSIONAHA.115.06624","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"d177364e-07f1-523d-aee1-d28f0d2e0235","evidence_kind":"source_excerpt","locator":"Lines 481-487","start_line":481,"end_line":487,"excerpt":"## taurine-vascular-dilation\nBlood-vessel function changed along with blood pressure.\nThe taurine arm in the same prehypertension trial improved both endothelium-dependent and endothelium-independent vasodilation.\nModel: Same 120-person randomized study.\nLimitations: Clinical and vascular endpoints from one trial are not independent trials.\nEvidence access: Primary abstract\nTaurine Supplementation Lowers Blood Pressure and Improves Vascular Function in Prehypertension: Randomized, Double-Blind, Placebo-Controlled Study. · 2016 · https://pubmed.ncbi.nlm.nih.gov/26781281/ · DOI 10.1161/HYPERTENSIONAHA.115.06624","model_system":"Same 120-person randomized study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc8d9ab8-fdf9-5107-877c-336cf8005097","stable_key":"import-1acdb1e8-2159-5c7f-b39f-0153ff8024ae","title":"Taurine: synthesis, transport, mitochondrial decoding and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"c6cb77619a374d9b1b04830032fdd3b33d269d160df5baba3778fad5adf57db5","revision_id":"cc45c491-cc6a-5426-ab72-d7c6d26c3614","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}