{"id":"02b5ed78-f082-5386-9c39-5c7a49bdf08e","stable_key":"584c58f5-ab9f-53f3-97a9-55783db943b0:tryptophan-muscle-kat-program","predicate":"increases_expression","statement":"The PGC-1alpha1–PPAR-alpha/delta program increased muscle kynurenine aminotransferases and conversion of kynurenine to kynurenic acid.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"2bec4d62-030a-5a39-a666-924cad864da2","mechanism_event_label":"Muscle metabolism can change which tryptophan products remain in circulation.","subject":{"id":"4570cff2-ef28-5d95-aa1f-570a357217cc","slug":"mouse-ppargc1a-isoform1","display_name":"Mouse PGC-1alpha1 / Ppargc1a isoform 1","entity_type_key":"protein"},"object":{"id":"8e62cc97-ebd5-592a-83ac-9386fc84f3ff","slug":"mouse-muscle-kynurenine-aminotransferases","display_name":"Mouse skeletal-muscle kynurenine aminotransferases; multiple enzymes","entity_type_key":"protein_state"},"evidence_count":1,"mechanism_event":{"id":"2bec4d62-030a-5a39-a666-924cad864da2","stable_key":"584c58f5-ab9f-53f3-97a9-55783db943b0:tryptophan-muscle-kat-program-event","event_type":"observed_relationship","label":"Muscle metabolism can change which tryptophan products remain in circulation.","description":"The PGC-1alpha1–PPAR-alpha/delta program increased muscle kynurenine aminotransferases and conversion of kynurenine to kynurenic acid.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"4570cff2-ef28-5d95-aa1f-570a357217cc","slug":"mouse-ppargc1a-isoform1","display_name":"Mouse PGC-1alpha1 / Ppargc1a isoform 1","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8e62cc97-ebd5-592a-83ac-9386fc84f3ff","slug":"mouse-muscle-kynurenine-aminotransferases","display_name":"Mouse skeletal-muscle kynurenine aminotransferases; 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do not assign the entire effect to human AADAT alone.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Tryptophan collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-tryptophan","display_name":"L-Tryptophan","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Muscle metabolism can change which tryptophan products remain in circulation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Skeletal muscle PGC-1α1 modulates kynurenine metabolism and mediates resilience to stress-induced depression. · 2014 · https://pubmed.ncbi.nlm.nih.gov/25259918/ · DOI 10.1016/j.cell.2014.07.051","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"e86d8da3-c692-5643-97bf-ad3febdfcf21","evidence_kind":"source_excerpt","locator":"Lines 610-616","start_line":610,"end_line":616,"excerpt":"## tryptophan-muscle-kat-program\nMuscle metabolism can change which tryptophan products remain in circulation.\nThe PGC-1alpha1–PPAR-alpha/delta program increased muscle kynurenine aminotransferases and conversion of kynurenine to kynurenic acid.\nModel: Mouse skeletal-muscle transgenic and stress experiments.\nLimitations: Multiple aminotransferases are involved; do not assign the entire effect to human AADAT alone.\nEvidence access: Primary abstract\nSkeletal muscle PGC-1α1 modulates kynurenine metabolism and mediates resilience to stress-induced depression. · 2014 · https://pubmed.ncbi.nlm.nih.gov/25259918/ · DOI 10.1016/j.cell.2014.07.051","model_system":"Mouse skeletal-muscle transgenic and stress experiments.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"73f9d3e7-fdc9-5418-8f3c-f4ef145f6efa","stable_key":"import-584c58f5-ab9f-53f3-97a9-55783db943b0","title":"Tryptophan: transport, protein synthesis, neuroactive metabolites, NAD and microbial pathways (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"7dfd20063b91900cb5c6ad675e3e675b7e25ef0fb8304eabac6f263cc5518284","revision_id":"bfafd789-fdf5-521f-bd28-c662e01ec1ea","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}