{"id":"028ede9f-a735-5e23-aaf3-a8c63fed09b5","stable_key":"44737fa3-b335-53f4-a644-b9878d4416ac:creatine-pcr-versus-atp-loading","predicate":"increased","statement":"Approximately 20% or more of the creatine taken up was recovered as phosphocreatine, while muscle ATP concentration did not change.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"441c6870-6ca0-5633-9aa2-1db5f2b43ead","mechanism_event_label":"More creatine expanded the phosphate reserve without simply raising resting ATP.","subject":{"id":"9f5df558-ed3d-5cda-b5ca-0f90f7aa6a8c","slug":"creatine","display_name":"Creatine","entity_type_key":"small_molecule"},"object":{"id":"088560cc-b8cb-5001-883b-9f32a6552699","slug":"muscle-phosphocreatine-content","display_name":"Skeletal-muscle phosphocreatine content","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"441c6870-6ca0-5633-9aa2-1db5f2b43ead","stable_key":"44737fa3-b335-53f4-a644-b9878d4416ac:creatine-pcr-versus-atp-loading-event","event_type":"observed_intervention","label":"More creatine expanded the phosphate reserve without simply raising resting ATP.","description":"Approximately 20% or more of the creatine taken up was recovered as phosphocreatine, while muscle ATP concentration did not change.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"c081984a-e118-582f-ac46-6a767f8f0bf2","slug":"phosphocreatine","display_name":"Phosphocreatine","entity_type_key":"small_molecule"},"role":"increased_pool","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"58b974f1-d389-5bf6-81cd-889c44442c42","slug":"atp","display_name":"ATP","entity_type_key":"small_molecule"},"role":"unchanged_pool","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"9f5df558-ed3d-5cda-b5ca-0f90f7aa6a8c","slug":"creatine","display_name":"Creatine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"088560cc-b8cb-5001-883b-9f32a6552699","slug":"muscle-phosphocreatine-content","display_name":"Skeletal-muscle phosphocreatine content","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/creatine-research/1327657.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"3ae0516c0f0465293ac00446b6a863fa2d791a750258a11b532c1247fdb47bd6\", \"start_char\": 0, \"end_char\": 1573, \"text_sha256\": \"3ae0516c0f0465293ac00446b6a863fa2d791a750258a11b532c1247fdb47bd6\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Oral loading with muscle biopsies","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"5 g creatine four to six times daily for two or more days","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Loading study, not evidence that everyone is deficient; the indexed abstract is truncated and no unreported exercise effect is extracted.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Creatine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"creatine","display_name":"Creatine","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"17 human participants","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"More creatine expanded the phosphate reserve without simply raising resting ATP.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[creatine-p1327657] Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation. (1992). https://pubmed.ncbi.nlm.nih.gov/1327657/ DOI: 10.1042/cs0830367","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Skeletal muscle and blood","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"54e477b2-c446-51bc-821d-3a8a554dae73","evidence_kind":"source_excerpt","locator":"Lines 945-956","start_line":945,"end_line":956,"excerpt":"### creatine-pcr-versus-atp-loading\nApproximately 20% or more of the creatine taken up was recovered as phosphocreatine, while muscle ATP concentration did not change.\nCondition category: normal\nnutrient_topic: Creatine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: More creatine expanded the phosphate reserve without simply raising resting ATP.\norganism: 17 human participants\ntissue_or_cell_type: Skeletal muscle and blood\nexperimental_model: Oral loading with muscle biopsies\nlimitations: Loading study, not evidence that everyone is deficient; the indexed abstract is truncated and no unreported exercise effect is extracted.\nexposure: 5 g creatine four to six times daily for two or more days\nevidence_span: {\"source_cache\": \"artifacts/creatine-research/1327657.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"3ae0516c0f0465293ac00446b6a863fa2d791a750258a11b532c1247fdb47bd6\", \"start_char\": 0, \"end_char\": 1573, \"text_sha256\": \"3ae0516c0f0465293ac00446b6a863fa2d791a750258a11b532c1247fdb47bd6\"}\n[creatine-p1327657] Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation. 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