{"id":"02453161-b929-5302-893a-b7db4729d389","stable_key":"53d9b98d-e3a0-5416-bc88-adbe42a8cb1b:curcumin-uc-response","predicate":"increases","statement":"Clinical response occurred in 17/26 versus 3/24 participants.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"740b7df4-4acb-582c-9fc2-1e47817472e7","mechanism_event_label":"More participants also met the symptom-response criterion.","subject":{"id":"0e625439-d093-5d1b-8713-dcfdafcf6811","slug":"curcumin","display_name":"Curcumin","entity_type_key":"small_molecule"},"object":{"id":"eb0e22a0-da98-5716-a473-d3db28e7bb64","slug":"uc-clinical-response","display_name":"Clinical response of ulcerative colitis in the specified trial","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"740b7df4-4acb-582c-9fc2-1e47817472e7","stable_key":"53d9b98d-e3a0-5416-bc88-adbe42a8cb1b:curcumin-uc-response-event","event_type":"observed_intervention","label":"More participants also met the symptom-response criterion.","description":"Clinical response occurred in 17/26 versus 3/24 participants.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e9d452ca-d805-5435-81bc-6ef4c587c967","slug":"mesalamine","display_name":"Mesalamine","entity_type_key":"small_molecule"},"role":"continued_background_therapy","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"0e625439-d093-5d1b-8713-dcfdafcf6811","slug":"curcumin","display_name":"Curcumin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"eb0e22a0-da98-5716-a473-d3db28e7bb64","slug":"uc-clinical-response","display_name":"Clinical response of ulcerative colitis in the specified trial","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/curcumin-research/25724700.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"470d55e94365249fc0b737c0b177188f2d4a968cd148b71c3ee6c621189cd09e\", \"start_char\": 0, \"end_char\": 1945, \"text_sha256\": \"470d55e94365249fc0b737c0b177188f2d4a968cd148b71c3ee6c621189cd09e\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Multicenter randomized trial in 50 mesalamine-treated adults","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Curcumin 3 g/day or placebo for one month with continuing mesalamine","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Adjunctive treatment, not curcumin monotherapy. 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(2015). https://pubmed.ncbi.nlm.nih.gov/25724700/ DOI: 10.1016/j.cgh.2015.02.019","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Mild-to-moderate active ulcerative colitis","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"3ba1cebc-f3f4-5575-a6b0-5e93e201d376","evidence_kind":"source_excerpt","locator":"Lines 1048-1059","start_line":1048,"end_line":1059,"excerpt":"### curcumin-uc-response\nClinical response occurred in 17/26 versus 3/24 participants.\nCondition category: normal\nnutrient_topic: Curcumin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: More participants also met the symptom-response criterion.\norganism: Homo sapiens\ntissue_or_cell_type: Mild-to-moderate active ulcerative colitis\nexperimental_model: Multicenter randomized trial in 50 mesalamine-treated adults\nlimitations: Adjunctive treatment, not curcumin monotherapy. Small study and wide confidence intervals; molecular mediation not demonstrated.\nexposure: Curcumin 3 g/day or placebo for one month with continuing mesalamine\nevidence_span: {\"source_cache\": \"artifacts/curcumin-research/25724700.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"470d55e94365249fc0b737c0b177188f2d4a968cd148b71c3ee6c621189cd09e\", \"start_char\": 0, \"end_char\": 1945, \"text_sha256\": \"470d55e94365249fc0b737c0b177188f2d4a968cd148b71c3ee6c621189cd09e\"}\n[curcumin-p25724700] Curcumin in Combination With Mesalamine Induces Remission in Patients With Mild-to-Moderate Ulcerative Colitis in a Randomized Controlled Trial. 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