{"id":"01f323bc-d062-5f4d-9924-229f642a9928","stable_key":"3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd:silica-silanol-membrane","predicate":"promotes","statement":"Particle surface treatments linked nearly free silanols to membranolysis and inflammatory activity.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"89434a76-3e97-5d46-bba1-b032eddd043f","mechanism_event_label":"Surface chemistry helps explain why silica preparations differ.","subject":{"id":"42c3c2f2-e2a2-5e81-b3de-f8b3374a31f2","slug":"silica-nearly-free-silanols","display_name":"Nearly free surface silanols on silica particles","entity_type_key":"chemical_species"},"object":{"id":"ff46fc72-879a-59bb-a2cc-b3f788947f8f","slug":"silica-membrane-disruption","display_name":"Membrane disruption by silica particles","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"89434a76-3e97-5d46-bba1-b032eddd043f","stable_key":"3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd:silica-silanol-membrane-event","event_type":"observed_relationship","label":"Surface chemistry helps explain why silica preparations differ.","description":"Particle surface treatments linked nearly free silanols to membranolysis and inflammatory activity.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"42c3c2f2-e2a2-5e81-b3de-f8b3374a31f2","slug":"silica-nearly-free-silanols","display_name":"Nearly free surface silanols on silica particles","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ff46fc72-879a-59bb-a2cc-b3f788947f8f","slug":"silica-membrane-disruption","display_name":"Membrane disruption by silica particles","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"11b1cdb5-1b10-586b-9917-b4da18ac072f","slug":"silica","display_name":"Silica and soluble silicon","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"b2d4231b-3893-5d4e-8b52-d0effdaa26c9","slug":"crystalline-silica","display_name":"Crystalline silica / quartz particles","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"5eb47f46-5727-5236-8e42-c2c85ed5c66a","slug":"amorphous-silica-particles","display_name":"Amorphous silica particles","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Characterized quartz/amorphous particles, membrane assays, macrophages and rat exposure program.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Surface motif is not a dissolved nutrient species; 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no oral-dose inference.\nEvidence access: Primary full text\nNearly free surface silanols are the critical molecular moieties that initiate the toxicity of silica particles. · 2020 · https://pubmed.ncbi.nlm.nih.gov/33097669/ · DOI 10.1073/pnas.2008006117","model_system":"Characterized quartz/amorphous particles, membrane assays, macrophages and rat exposure program.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc4b461e-dd46-57ab-8213-8aeb7ff9e8d0","stable_key":"import-3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd","title":"Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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