{"id":"01c94e4f-fa86-5d90-9fa0-49d620657e8f","stable_key":"3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd:silica-microcarrier-hif","predicate":"associated_with_stabilization","statement":"Silicon-releasing microcarriers increased HIF1A expression and stabilization, attributed to reduced PHD2 activity in HUVECs.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"ebcf7aed-20d6-5ad3-8578-b34605515f8d","mechanism_event_label":"A biomaterial study implicated oxygen-sensing machinery.","subject":{"id":"991b0aee-d3b1-5fdc-bb9b-dd49d00b0bd2","slug":"mesoporous-silica-microcarriers","display_name":"Mesoporous silica microcarriers","entity_type_key":"chemical_species"},"object":{"id":"22b3e241-94b0-55fd-a233-c63af92520d8","slug":"hif1a","display_name":"HIF-1 alpha","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"ebcf7aed-20d6-5ad3-8578-b34605515f8d","stable_key":"3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd:silica-microcarrier-hif-event","event_type":"observed_relationship","label":"A biomaterial study implicated oxygen-sensing machinery.","description":"Silicon-releasing microcarriers increased HIF1A expression and stabilization, attributed to reduced PHD2 activity in HUVECs.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"991b0aee-d3b1-5fdc-bb9b-dd49d00b0bd2","slug":"mesoporous-silica-microcarriers","display_name":"Mesoporous silica microcarriers","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"22b3e241-94b0-55fd-a233-c63af92520d8","slug":"hif1a","display_name":"HIF-1 alpha","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"11b1cdb5-1b10-586b-9917-b4da18ac072f","slug":"silica","display_name":"Silica and soluble silicon","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"8681acd7-4f56-59e0-a757-37b8376c8bde","slug":"egln1","display_name":"EGLN1 / PHD2","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"59d6d1cd-df32-5b58-b950-3188bc7b95d6","slug":"iron-ii","display_name":"Ferrous iron","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""},{"entity":{"id":"38d0c4d9-53d1-5239-bfe3-c1b5e9b79085","slug":"ascorbate","display_name":"L-Ascorbate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":5,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human endothelial cells; released silicon in the ppm range.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Accessed abstract does not establish direct inhibitor binding; HIF PHD2 differs from collagen prolyl hydroxylase.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"silica","display_name":"Silica and soluble silicon","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"A biomaterial study implicated oxygen-sensing machinery.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Promoting angiogenesis with mesoporous microcarriers through a synergistic action of delivered silicon ion and VEGF. · 2017 · https://pubmed.ncbi.nlm.nih.gov/27918936/ · DOI 10.1016/j.biomaterials.2016.11.053","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"bf1aa176-2a30-5ea1-a466-ba79d8735b9f","evidence_kind":"source_excerpt","locator":"Lines 272-278","start_line":272,"end_line":278,"excerpt":"## silica-microcarrier-hif\nA biomaterial study implicated oxygen-sensing machinery.\nSilicon-releasing microcarriers increased HIF1A expression and stabilization, attributed to reduced PHD2 activity in HUVECs.\nModel: Human endothelial cells; released silicon in the ppm range.\nLimitations: Accessed abstract does not establish direct inhibitor binding; HIF PHD2 differs from collagen prolyl hydroxylase.\nEvidence access: Primary abstract\nPromoting angiogenesis with mesoporous microcarriers through a synergistic action of delivered silicon ion and VEGF. · 2017 · https://pubmed.ncbi.nlm.nih.gov/27918936/ · DOI 10.1016/j.biomaterials.2016.11.053","model_system":"Human endothelial cells; released silicon in the ppm range.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc4b461e-dd46-57ab-8213-8aeb7ff9e8d0","stable_key":"import-3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd","title":"Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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