{"id":"017a39ec-3f88-5827-9032-e73b8ea7440a","stable_key":"8c946991-97f0-55ee-8df0-00e67621962f:nad-plus-slc51-respiration","predicate":"deletion_reduces","statement":"MCART1/SLC25A51-null human cells had reduced mitochondrial NAD+/NADH, TCA-cycle flux, respiration and complex-I activity.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"69f04549-d0b8-55f7-8544-f854fa245e9a","mechanism_event_label":"A functioning NAD supply outside mitochondria cannot compensate for a broken mitochondrial entry route.","subject":{"id":"8e44149a-f765-546f-a27e-69cc9590e4cf","slug":"slc25a51","display_name":"SLC25A51","entity_type_key":"protein"},"object":{"id":"d3bd2c8f-2e90-5551-b5d7-9e17ee5d4058","slug":"human-slc25a51-dependent-respiration","display_name":"Respiration supported by SLC25A51 in human cells","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"69f04549-d0b8-55f7-8544-f854fa245e9a","stable_key":"8c946991-97f0-55ee-8df0-00e67621962f:nad-plus-slc51-respiration-event","event_type":"observed_relationship","label":"A functioning NAD supply outside mitochondria cannot compensate for a broken mitochondrial entry route.","description":"MCART1/SLC25A51-null human cells had reduced mitochondrial NAD+/NADH, TCA-cycle flux, respiration and complex-I activity.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8e44149a-f765-546f-a27e-69cc9590e4cf","slug":"slc25a51","display_name":"SLC25A51","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d3bd2c8f-2e90-5551-b5d7-9e17ee5d4058","slug":"human-slc25a51-dependent-respiration","display_name":"Respiration supported by SLC25A51 in human cells","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"283ed24b-06a1-50aa-9281-df3bac6ce37e","slug":"nad-plus","display_name":"NAD+","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"9fbf2e03-16a9-5ca7-965c-0bfc07ca24da","slug":"nadh","display_name":"NADH","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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