{"id":"011e3171-2102-54bc-b39b-ce2aef78b58c","stable_key":"fd7915ff-856d-56c2-a118-4989693a7644:gingerols-6-rat-metabolism","predicate":"is_metabolized_to","statement":"NADPH-fortified rat hepatic microsomes converted 6-gingerol into a mixture of tentatively identified metabolites.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"79d89711-b8a2-5a1f-8909-854b049c3777","mechanism_event_label":"NADPH-fortified rat hepatic microsomes converted 6-gingerol into a mixture of tentatively identified metabolites.","subject":{"id":"837fdd65-c1eb-52e0-a724-42a1e9065c82","slug":"6-gingerol","display_name":"6-Gingerol","entity_type_key":"small_molecule"},"object":{"id":"9bb1f8e4-c3a7-5090-ab29-ff1ed14c130d","slug":"rat-microsomal-6-gingerol-metabolite-mixture","display_name":"Rat microsomal 6-gingerol metabolite mixture","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"79d89711-b8a2-5a1f-8909-854b049c3777","stable_key":"fd7915ff-856d-56c2-a118-4989693a7644:gingerols-6-rat-metabolism-event","event_type":"observed_relationship","label":"NADPH-fortified rat hepatic microsomes converted 6-gingerol into a mixture of tentatively identified metabolites.","description":"NADPH-fortified rat hepatic microsomes converted 6-gingerol into a mixture of tentatively identified metabolites.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"837fdd65-c1eb-52e0-a724-42a1e9065c82","slug":"6-gingerol","display_name":"6-Gingerol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9bb1f8e4-c3a7-5090-ab29-ff1ed14c130d","slug":"rat-microsomal-6-gingerol-metabolite-mixture","display_name":"Rat microsomal 6-gingerol metabolite mixture","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"4aba2a5e-8d06-5304-bb01-c0402b225a94","slug":"nadph","display_name":"NADPH","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"6-Gingerol with NADPH; exact concentrations not in accessed abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Not specified in accessed abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation, not universally established human effects","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Rat hepatic microsomes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Metabolite assignments were tentative; neither a specific human CYP nor dietary NADPH depletion is established.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Gingerols collection; each molecular form and experimental preparation remains explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"gingerols","display_name":"Gingerols","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Rat hepatic microsomes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"NADPH-fortified rat hepatic microsomes converted 6-gingerol into a mixture of tentatively identified metabolites.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Microsomal hydroxylation and glucuronidation of [6]-gingerol. (2006). https://pubmed.ncbi.nlm.nih.gov/17090120/ DOI: 10.1021/jf062235l","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"In vitro microsomal incubation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Liver microsomal preparation","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"a94fb08a-4f0c-52b3-a46e-e36528159db9","evidence_kind":"source_excerpt","locator":"Lines 261-270","start_line":261,"end_line":270,"excerpt":"## gingerols-6-rat-metabolism\nNADPH-fortified rat hepatic microsomes converted 6-gingerol into a mixture of tentatively identified metabolites.\nModel/species: Rat hepatic microsomes\nTissue: Liver microsomal preparation\nExposure: 6-Gingerol with NADPH; exact concentrations not in accessed abstract\nRoute: In vitro microsomal incubation\nDuration: Not specified in accessed abstract\nLimits: Metabolite assignments were tentative; neither a specific human CYP nor dietary NADPH depletion is established.\nPrimary reference: Microsomal hydroxylation and glucuronidation of [6]-gingerol. (2006). https://pubmed.ncbi.nlm.nih.gov/17090120/ DOI: 10.1021/jf062235l\nAccess: Primary PubMed abstract.","model_system":"Rat hepatic microsomes","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact archived synthesis span with its primary citation; original paraphrase, not a claimed publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1107d60b-8e2d-55d7-8f5d-5612c49aa7dc","stable_key":"import-fd7915ff-856d-56c2-a118-4989693a7644","title":"Gingerols: mechanisms, molecular forms and cross-actor connections (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted curation of thirteen primary research papers; study-specific PubMed/DOI links and limitations retained. 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