{"id":"0110cbd0-0993-513a-94a8-6c55b85861b2","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:a-vision-deficiency-repletion","predicate":"restores","statement":"Visual function normalized within eight days of vitamin A treatment in the three reported deficient patients.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"2427aebd-b2a6-5b1a-ab71-f9613c0d8598","mechanism_event_label":"Repletion reversed the measured visual deficit in this series.","subject":{"id":"ce392c9e-6483-5914-b18b-d6a2520dbbf6","slug":"vitamin-a","display_name":"Vitamin A","entity_type_key":"chemical_species"},"object":{"id":"b2bdb49e-80cb-5dec-af2d-e44051383ad4","slug":"visual-sensitivity","display_name":"Visual sensitivity","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"2427aebd-b2a6-5b1a-ab71-f9613c0d8598","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:a-vision-deficiency-repletion-event","event_type":"observed_intervention","label":"Repletion reversed the measured visual deficit in this series.","description":"Visual function normalized within eight days of vitamin A treatment in the three reported deficient patients.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ce392c9e-6483-5914-b18b-d6a2520dbbf6","slug":"vitamin-a","display_name":"Vitamin A","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b2bdb49e-80cb-5dec-af2d-e44051383ad4","slug":"visual-sensitivity","display_name":"Visual sensitivity","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"experimental_model","value_text":"Before/after repletion follow-up","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Uncontrolled treatment observation; no dose recommendation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin A research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-a","display_name":"Vitamin A","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Repletion reversed the measured visual deficit in this series.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[kemp-1988] Visual function and rhodopsin levels in humans with vitamin A deficiency (1988). https://pubmed.ncbi.nlm.nih.gov/3350064/ DOI: 10.1016/S0014-4835(88)80076-9","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Retina","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"e9a84745-7297-5ac8-9e38-132628cb1a36","evidence_kind":"source_excerpt","locator":"Lines 1019-1028","start_line":1019,"end_line":1028,"excerpt":"### a-vision-deficiency-repletion\nVisual function normalized within eight days of vitamin A treatment in the three reported deficient patients.\nCondition category: nutrient_deficiency\nnutrient_topic: Vitamin A research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Repletion reversed the measured visual deficit in this series.\norganism: Homo sapiens\ntissue_or_cell_type: Retina\nexperimental_model: Before/after repletion follow-up\nlimitations: Uncontrolled treatment observation; no dose recommendation.\n[kemp-1988] Visual function and rhodopsin levels in humans with vitamin A deficiency (1988). https://pubmed.ncbi.nlm.nih.gov/3350064/ DOI: 10.1016/S0014-4835(88)80076-9","model_system":"Before/after repletion follow-up","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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