{"id":"00e5753b-54c3-5c12-9762-174b197a9ff0","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-thyroid-release","predicate":"inhibits","statement":"Lithium reduced hormonal and nonhormonal thyroid iodine release in human radioiodine kinetic studies.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"ebb89545-f229-580a-ae3c-e2d9888cab7a","mechanism_event_label":"Making thyroid hormone and releasing it are separate steps.","subject":{"id":"13b4b09c-4581-58f6-9792-9a78125963e8","slug":"lithium-ion","display_name":"Lithium ion (Li+)","entity_type_key":"ion"},"object":{"id":"162e3d6e-1363-5ee8-a8d8-2cd7a158ff5a","slug":"human-thyroid-iodine-release","display_name":"Human thyroid hormonal and nonhormonal iodine release","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"ebb89545-f229-580a-ae3c-e2d9888cab7a","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-thyroid-release-event","event_type":"observed_relationship","label":"Making thyroid hormone and releasing it are separate steps.","description":"Lithium reduced hormonal and nonhormonal thyroid iodine release in human radioiodine kinetic studies.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"13b4b09c-4581-58f6-9792-9a78125963e8","slug":"lithium-ion","display_name":"Lithium ion (Li+)","entity_type_key":"ion"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"162e3d6e-1363-5ee8-a8d8-2cd7a158ff5a","slug":"human-thyroid-iodine-release","display_name":"Human thyroid hormonal and nonhormonal iodine release","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8e2e3902-5e26-52e3-9c85-1d7c0ace1637","slug":"lithium","display_name":"Lithium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"83b11ca6-52c7-5a1b-8c39-d9cdf89244e3","slug":"iodide","display_name":"Iodide ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"f2b25f38-ec94-57d0-a46d-dd0fee45f01e","slug":"thyroxine","display_name":"T4","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Eight kinetic studies in seven thyrotoxic women; serum lithium about 1 mEq/L.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Compartment-model inference; not evidence that lithium simply removes iodine from the body.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Lithium collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lithium","display_name":"Lithium","entity_type_key":"nutrient_element"}},{"dimension":"plain_language","value_text":"Making thyroid hormone and releasing it are separate steps.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The use of lithium in the treatment of thyrotoxicosis. · 1972 · https://pubmed.ncbi.nlm.nih.gov/4115707/ · DOI 10.1172/JCI107094","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"4d894778-937a-5771-a9cc-30dc2664f4f2","evidence_kind":"source_excerpt","locator":"Lines 392-398","start_line":392,"end_line":398,"excerpt":"## lithium-thyroid-release\nMaking thyroid hormone and releasing it are separate steps.\nLithium reduced hormonal and nonhormonal thyroid iodine release in human radioiodine kinetic studies.\nModel: Eight kinetic studies in seven thyrotoxic women; serum lithium about 1 mEq/L.\nLimitations: Compartment-model inference; not evidence that lithium simply removes iodine from the body.\nEvidence access: Primary abstract\nThe use of lithium in the treatment of thyrotoxicosis. · 1972 · https://pubmed.ncbi.nlm.nih.gov/4115707/ · DOI 10.1172/JCI107094","model_system":"Eight kinetic studies in seven thyrotoxic women; serum lithium about 1 mEq/L.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"b2dd2f3c-5c4c-5a12-9a0d-91b521ffcf98","stable_key":"import-b7798a90-72a3-5454-a321-c4be88bf0cc4","title":"Lithium: metal-sensitive enzymes, transport and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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