{"id":"00a87692-41e9-502e-b4a3-f802e57337f0","stable_key":"availability:selenoprotein-biomarker-plateaus:1","predicate":"has_saturable_biomarker_relationship_with","statement":"SELENOP can rise with selenium supply and then approach a study-dependent plateau.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"source_reported: Human intervention for biomarker plateaus; supplied-source interpretation of measurement limits.","direction":"context_dependent","is_public":true,"mechanism_event_id":"6ca5745b-f56b-50bd-8291-249c6880b7d9","mechanism_event_label":"SELENOP can rise with selenium supply and then approach a study-dependent plateau.","subject":{"id":"dc89d7e2-8f89-577b-838f-42bf5d8ec7c8","slug":"selenium","display_name":"Selenium","entity_type_key":"nutrient_element"},"object":{"id":"c7fbd153-6444-50b2-a8be-6936e352a11c","slug":"selenop","display_name":"SELENOP","entity_type_key":"protein"},"evidence_count":2,"mechanism_event":{"id":"6ca5745b-f56b-50bd-8291-249c6880b7d9","stable_key":"availability:selenoprotein-biomarker-plateaus:1","event_type":"availability_dependent_change","label":"SELENOP can rise with selenium supply and then approach a study-dependent plateau.","description":"A selenium-responsive circulating biomarker approaches a plateau in a particular study or individual context. Human intervention dose-response observations and biomarker interpretation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"dc89d7e2-8f89-577b-838f-42bf5d8ec7c8","slug":"selenium","display_name":"Selenium","entity_type_key":"nutrient_element"},"role":"condition_input","stoichiometry":null,"state_label":"A selenium-responsive circulating biomarker approaches a plateau in a particular study or individual context.","sequence_order":0,"notes":""},{"entity":{"id":"c7fbd153-6444-50b2-a8be-6936e352a11c","slug":"selenop","display_name":"SELENOP","entity_type_key":"protein"},"role":"affected_component","stoichiometry":null,"state_label":"A selenium-responsive circulating biomarker approaches a plateau in a particular study or individual context.","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"A selenium-responsive circulating biomarker approaches a plateau in a particular study or individual context.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_scope","value_text":"Human intervention dose-response observations and biomarker interpretation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Study-specific plateaus cannot be mapped to GPX1 NMD, thyroid or immune failure, GPX4 loss, or an absolute antioxidant-to-pro-oxidant switch. Plasma and whole-blood values are not interchangeable.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"5add0e80-fd94-5a05-9082-ad8e0ff5898d","evidence_kind":"source_passage","locator":"lines 157-161","start_line":157,"end_line":161,"excerpt":"SELENOP plateau near ~125 µg/L in the Hurst trial\n\nHuman randomized dose-response trial\n\nStudy-specific plateau, not a universal treatment target [2]","model_system":"Supplied reference; verify the primary study and experimental context.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c788c19c-884c-5233-92b1-0bd063d87741","stable_key":"deficiency","title":"Selenium deficiency: a mechanism-first reference","document_type":"user_supplied_reference","citation_label":"Supplied selenium deficiency reference","file_path":"X:\\metabolic-ledger\\source_material\\selenium-deficiency-reference.md","sha256":"a3f14bc3fa24c595dda830664523090a7b5bfa76e9dcf517f42f62212ceb767e","revision_id":"f8f97804-c1fb-56df-9c06-c02e36e2a5b8","review_status":"unverified_draft","notes":"Preserved verbatim. Reported study types are source labels, not independent verification."}},{"id":"4fe906d7-9d45-5fc9-9af6-a0d667ab0797","evidence_kind":"source_passage","locator":"lines 569-575","start_line":569,"end_line":575,"excerpt":"SELENOP\n\nRises with selenium supply and can plateau\n\nFunctional selenium transport / selenoprotein-related status\n\nAcute-phase sensitive; assay availability limited","model_system":"Supplied reference; verify the primary study and experimental context.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c788c19c-884c-5233-92b1-0bd063d87741","stable_key":"deficiency","title":"Selenium deficiency: a mechanism-first reference","document_type":"user_supplied_reference","citation_label":"Supplied selenium deficiency reference","file_path":"X:\\metabolic-ledger\\source_material\\selenium-deficiency-reference.md","sha256":"a3f14bc3fa24c595dda830664523090a7b5bfa76e9dcf517f42f62212ceb767e","revision_id":"f8f97804-c1fb-56df-9c06-c02e36e2a5b8","review_status":"unverified_draft","notes":"Preserved verbatim. Reported study types are source labels, not independent verification."}}],"relations":[],"conflicts":[],"corrections":[],"research":null}