{"id":"00973332-af24-5dde-84f3-6cbaeccceaa3","stable_key":"6660bba2-4fa0-590a-bf52-9803a24bea9f:autonomic-blood-pressure","predicate":"increases_in_recorded_experiment","statement":"Modafinil increased resting blood pressure in the controlled human autonomic study.","claim_class":"observational","status":"source_recorded","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"f36e8c16-074c-5a37-8a22-829be9ffde1e","mechanism_event_label":"Modafinil increased resting blood pressure in the controlled human autonomic study.","subject":{"id":"624e6a4b-f96d-5d12-8206-30d1e1715c26","slug":"modafinil","display_name":"Modafinil","entity_type_key":"drug"},"object":{"id":"88c28877-a08b-5763-818f-439e2aef26f4","slug":"human-blood-pressure","display_name":"Human blood pressure","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"f36e8c16-074c-5a37-8a22-829be9ffde1e","stable_key":"6660bba2-4fa0-590a-bf52-9803a24bea9f:autonomic-blood-pressure-event","event_type":"experimental_observation","label":"Modafinil increased resting blood pressure in the controlled human autonomic study.","description":"A controlled 12-person human study found increased resting heart rate and blood pressure and higher catecholamine measures after modafinil. However, measured peroneal sympathetic nerve activity during tilt was attenuated. This is a differentiated autonomic response, not every sympathetic output increasing together. Arousal and individual cardiovascular endpoints need separate records. [Autonomic study](https://pubmed.ncbi.nlm.nih.gov/15753235/)","status":"provisional","compartment":null,"participants":[{"entity":{"id":"624e6a4b-f96d-5d12-8206-30d1e1715c26","slug":"modafinil","display_name":"Modafinil","entity_type_key":"drug"},"role":"tested factor","stoichiometry":null,"state_label":"Modafinil","sequence_order":0,"notes":""},{"entity":{"id":"88c28877-a08b-5763-818f-439e2aef26f4","slug":"human-blood-pressure","display_name":"Human blood pressure","entity_type_key":"cellular_process"},"role":"measured outcome","stoichiometry":null,"state_label":"increase","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary indexed abstract checked; full methods and figures not comprehensively reviewed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_contrast","value_text":"{\"intervention\": \"Modafinil\", \"comparator\": \"Placebo/control\", \"endpoint\": \"Modafinil increased resting blood pressure in the controlled human autonomic study.\", \"effect_direction\": \"increase\", \"combination\": \"single\", \"conditions\": []}","comparator":null,"unit":null,"notes":"Explicit extracted experimental comparison; source-derived draft.","entity":null},{"dimension":"experimental_model","value_text":"Controlled twelve-person autonomic physiology study; other sympathetic readouts did not all increase.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Interpret only within the recorded preparation, exposure and comparator. The complete source passage retains qualifications; unspecified doses/timing have not been extracted here. No clinical efficacy, nutrient deficiency or unique molecular mediation is inferred.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Modafinil increased resting blood pressure in the controlled human autonomic study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Modafinil elicits sympathomedullary activation. | 2005 | DOI 10.1161/01.hyp.0000158267.66763.63 | PMID 15753235 | https://pubmed.ncbi.nlm.nih.gov/15753235/","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference lines 140-140; exact primary location described in quoted passage where extracted.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"e2e62094-421f-503e-902e-a403b64f2c63","evidence_kind":"source_excerpt","locator":"Lines 140-140","start_line":140,"end_line":140,"excerpt":"A controlled 12-person human study found increased resting heart rate and blood pressure and higher catecholamine measures after modafinil. However, measured peroneal sympathetic nerve activity during tilt was attenuated. This is a differentiated autonomic response, not every sympathetic output increasing together. Arousal and individual cardiovascular endpoints need separate records. [Autonomic study](https://pubmed.ncbi.nlm.nih.gov/15753235/)","model_system":"Controlled twelve-person autonomic physiology study; other sympathetic readouts did not all increase.","directness":"reported_statement","verification_status":"source_recorded","notes":"Exact excerpt of the retained AI-assisted reviewed reference; primary sources are cited in primary_references and access scope is retained. 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