{"id":"005767eb-4ca7-553f-b743-7ad5731a1362","stable_key":"434e1e27-eb90-583a-956b-62472726ffba:enamel-calcium-in-substituted-apatite","predicate":"mineral_component_of","statement":"Human enamel crystallites have an apatite lattice containing calcium and phosphate, with heterogeneous magnesium, sodium, fluoride and carbonate substitutions.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"b9c36a62-198e-50d3-b482-ee54dff607db","mechanism_event_label":"Tooth enamel is built from chemically varied calcium phosphate crystals.","subject":{"id":"d515a301-29a6-5d2d-88db-44773711406a","slug":"hydroxyapatite","display_name":"Hydroxyapatite / biological substituted apatite","entity_type_key":"chemical_species"},"object":{"id":"a475e475-a970-5461-a487-be7cdebc6db7","slug":"tooth-enamel","display_name":"Tooth enamel","entity_type_key":"tissue"},"evidence_count":1,"mechanism_event":{"id":"b9c36a62-198e-50d3-b482-ee54dff607db","stable_key":"434e1e27-eb90-583a-956b-62472726ffba:enamel-calcium-in-substituted-apatite-event","event_type":"biochemical_relationship","label":"Tooth enamel is built from chemically varied calcium phosphate crystals.","description":"Human enamel crystallites have an apatite lattice containing calcium and phosphate, with heterogeneous magnesium, sodium, fluoride and carbonate substitutions.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d515a301-29a6-5d2d-88db-44773711406a","slug":"hydroxyapatite","display_name":"Hydroxyapatite / biological substituted apatite","entity_type_key":"chemical_species"},"role":"solid_mineral","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e359bc15-e675-5d83-b0fe-1d70814e130b","slug":"calcium-ion","display_name":"Calcium ion","entity_type_key":"ion"},"role":"lattice_constituent_not_free_solute","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ee63fe8e-92f3-552f-8049-a5f1fa1e1523","slug":"phosphate-ion","display_name":"Inorganic phosphate (Pi; protonation depends on pH)","entity_type_key":"ion"},"role":"mineral_constituent","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"a475e475-a970-5461-a487-be7cdebc6db7","slug":"tooth-enamel","display_name":"Tooth enamel","entity_type_key":"tissue"},"role":"mineralized_tissue","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Atomic-scale imaging and correlative spectroscopy","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A structural tissue study; it does not test dietary calcium intake or enamel regeneration.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Calcium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"calcium","display_name":"Calcium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Tooth enamel is built from chemically varied calcium phosphate crystals.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[derocher2020] Chemical gradients in human enamel crystallites (2020). https://pmc.ncbi.nlm.nih.gov/articles/PMC8290891/ DOI: 10.1038/s41586-020-2433-3","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Dental enamel","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"e0cd56e7-068e-5cd4-beb4-dbe39efed441","evidence_kind":"source_excerpt","locator":"Lines 886-895","start_line":886,"end_line":895,"excerpt":"### enamel-calcium-in-substituted-apatite\nHuman enamel crystallites have an apatite lattice containing calcium and phosphate, with heterogeneous magnesium, sodium, fluoride and carbonate substitutions.\nCondition category: normal\nnutrient_topic: Calcium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Tooth enamel is built from chemically varied calcium phosphate crystals.\norganism: Homo sapiens\ntissue_or_cell_type: Dental enamel\nexperimental_model: Atomic-scale imaging and correlative spectroscopy\nlimitations: A structural tissue study; it does not test dietary calcium intake or enamel regeneration.\n[derocher2020] Chemical gradients in human enamel crystallites (2020). https://pmc.ncbi.nlm.nih.gov/articles/PMC8290891/ DOI: 10.1038/s41586-020-2433-3","model_system":"Atomic-scale imaging and correlative spectroscopy","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [derocher2020] Chemical gradients in human enamel crystallites (2020). https://pmc.ncbi.nlm.nih.gov/articles/PMC8290891/ DOI: 10.1038/s41586-020-2433-3","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3c083fa0-59c6-50e9-af42-678d0e3c1006","stable_key":"import-434e1e27-eb90-583a-956b-62472726ffba","title":"Calcium: mechanism-first literature curation (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"965c934d6b147f2b62f8d45ce6d7a87681a600bfe5c46a585b4704889afd3fc1","revision_id":"543ec48b-4f70-5197-9d76-f5a3c443664c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}