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Small experimental cohorts do not establish a population-wide threshold.\nexposure: 28 days of egg-white diet followed by general diet with or without 80 micrograms supplemental biotin\nevidence_span: {\"source_cache\": \"artifacts/biotin-research/12399279.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"38158dd10cfc6528b65a3304fac58a5b5d8ec82e20673534b5bf6e9e79f14b09\", \"start_char\": 0, \"end_char\": 1718, \"text_sha256\": \"38158dd10cfc6528b65a3304fac58a5b5d8ec82e20673534b5bf6e9e79f14b09\"}\n[b7-p12399279] Indicators of marginal biotin deficiency and repletion in humans: validation of 3-hydroxyisovaleric acid excretion and a leucine challenge. 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